Chest pain after staying up all night may be caused by peptic ulcer, coronary artery spasm, vegetative nerve disorders and other reasons. 1. Peptic ulcer: long stay up late will lead to excessive secretion of gastric acid, triggering peptic ulcer, duodenal ulcer manifested as hunger pains, pain at night, gastric ulcer manifested as pain after meals, gastric acid reflux stimulation of the esophageal mucosa will also have the symptom of hidden chest pain. 2. Coronary artery spasm: long-term late night life and routine will be irregular, may cause coronary artery spasm, myocardial microcirculation disorders, myocardial ischemia will have the symptom of hidden chest pain. 3. Plant nerve disorders: long-term late night may cause plant nerve disorders, there will also be a vague pain in the chest, accompanied by chest tightness, breathlessness, panic and other symptoms. Chest pain after staying up late for a variety of reasons, serious to go to the hospital for examination and treatment, try to minimize staying up late.