Liver cysts are a common and frequent clinical condition. In general, for liver cysts that are small in size and do not cause obvious symptoms, a close clinical observation approach can be taken and no specific treatment is required to avoid excessive trauma. Once a patient’s liver cyst has gradually increased in size and caused significant symptoms, surgical intervention is often required. Ultrasound-guided percutaneous hepatic cyst aspiration is one of the more commonly used treatment methods. Is there any significant pain associated with puncture aspiration of liver cysts? Ultrasound-guided percutaneous hepatic cyst puncture and drainage is primarily indicated for patients with liver cysts larger than six centimeters in size and who are too old to tolerate surgical treatment with general anesthesia. Since ultrasound-guided percutaneous liver cyst aspiration is often performed with local anesthesia, the patient is awake, which can add to the patient’s fear and nervousness. If the patient is under local anesthesia that is more extensive, the liver peritoneum is also anesthetized, and the patient himself is more tolerant of pain. When the liver cyst is punctured and aspirated, it is not accompanied by obvious pain symptoms. In this case, the patient’s cooperation is good, and the cystic fluid can be aspirated smoothly from the liver cyst, and a better treatment effect can be achieved. If the patient’s own tolerance for pain is poor and when performing puncture drainage of liver abscesses, so that the scope of anesthesia is small and does not provide adequate anesthesia to the liver peritoneum. In this case, during the process of fine dust puncture, the patient will indeed be accompanied by obvious pain symptoms, and some patients will not even be able to tolerate the pain and will not be able to fully cooperate. This can lead to poor treatment results and even to paracommunication of the abdominal organs.