Generalized swelling of pancreatic cancer in the late stage generally survives for 3-12 months, but it should be analyzed according to the individual’s physical condition, treatment plan, and psychological state. Pancreatic cancer is mainly a malignant tumor occurring in the epithelium of pancreatic ducts and pancreatic blast cells, which can be induced by poor dietary environment, obesity, long-term smoking, chronic damage to the pancreas, etc. Clinical symptoms are manifested as low back pain, epigastric discomfort, dyspepsia, diarrhea, jaundice, etc., and it is mostly treated by radical surgery, radiotherapy, chemotherapy and other ways. Generalized swelling in late stage of pancreatic cancer may be due to hypoproteinemia and deterioration of the condition. In the late stage of pancreatic cancer, if the patients have a more optimistic mentality, keep up with nutrition and actively cooperate with the doctor’s treatment, the survival time can be improved, and it is possible to reach a survival time of 12 months, if the patients have a worse physical condition and are intolerant of chemo-radiotherapy, then the survival time is generally shorter, and it is possible that they will survive for 3 months. It is recommended to keep a good mindset in normal life and actively cooperate with the doctor’s treatment.