Pancreatic cancer usually does not compress the recurrent laryngeal nerve, and the compression of recurrent laryngeal nerve is usually caused by chest or neck lesions. The recurrent laryngeal nerve is the main motor nerve of the larynx, divided into left recurrent laryngeal nerve and right recurrent laryngeal nerve, which innervates all the muscles of the larynx except cricothyroid muscle; in addition, it belongs to the mixed nerve, whose sensory fibers are distributed to the laryngeal mucous membranes below the glottis fissure. Unilateral damage or compression of the recurrent laryngeal nerve can lead to hoarseness, while bilateral damage to the recurrent laryngeal nerve can lead to choking and respiratory distress. The left recurrent laryngeal nerve crosses the aorta and returns to the larynx, while the right reflex returns to the larynx before the subclavian artery, and the left recurrent laryngeal nerve travels a longer route than the right. Therefore, lesions that compress the recurrent laryngeal nerve are cervical or thoracic lesions. The primary pancreatic cancer usually does not compress the recurrent laryngeal nerve. Instead, lymph node metastases from pancreatic cancer may compress the recurrent laryngeal nerve, with symptoms as described above. If pancreatic cancer is suspected or diagnosed, it is recommended to go to a regular hospital for comprehensive evaluation of the condition and follow the doctor’s instructions to avoid delaying the condition.