The 5-year survival rate of advanced brain metastasis of lung adenocarcinoma is about 5%. The exact survival period cannot be determined and will be affected by the patient’s condition, mentality and degree of cooperation. Lung adenocarcinoma is a kind of malignant tumor of lung, which has a very high mortality rate. When the disease develops to the advanced stage and metastatic foci are also present, the survival period of the patients is usually not particularly ideal. If lung adenocarcinoma advanced brain metastasis occurs, the patient is depressed and does not actively cooperate with doctor’s treatment, the survival time may be very short. However, if the patients with advanced lung adenocarcinoma brain metastasis are optimistic, have tenacious faith, strong physical resistance and actively cooperate with doctor’s treatment, the survival period may be relatively longer. Therefore, patients with advanced lung adenocarcinoma with brain metastasis need to keep positive attitude and cooperate with doctors for active treatment, which can effectively prolong the survival time and improve the quality of life.