Gallbladder removal may cause colon cancer. Bile is not secreted by the gallbladder, but by the liver cells of the liver after the secretion of the gallbladder is a storehouse of bile, after the removal of the gallbladder, bile may be transported directly through the extrahepatic bile ducts to the duodenum, the small intestine, the colorectum, and so on. The bile breakdown product, methylcholanthrene, is a carcinogen, and the mucosa of the large intestine can be stimulated by methylcholanthrene, thus increasing the chance of cancer. Gallbladder removal can promote the proliferation of the intestinal mucosa. The liver secretes primary bile acids, which are converted to secondary bile acids when they come into contact with bacteria. After gallbladder removal, primary bile acids will flow into the intestines in a steady stream, and contact with bacteria, transforming into secondary bile acids, and secondary bile acids may cause the development of colon cancer. Therefore, patients after gallbladder removal should eat more fresh vegetables and fruits, eat less spicy and stimulating food, and report to the doctor for treatment in case of discomfort.