The cause of pneumoconiosis is mainly exposure to dust at work, but some other causes can increase the chances of patients suffering from pneumoconiosis. 1, a large number of inhalation of productive dust: long-term dust pollution environment, which is the main cause of pneumoconiosis, and the more silica content in the dust, the shorter the course of the disease, the more serious; dust concentration, the higher the dispersion, the longer the exposure time, the more serious the disease. 2, people suffering from certain hereditary diseases or genetic defects: such as congenital lack of certain metabolic enzymes, so that their own defense function is reduced, belong to the susceptible. 3, age and gender differences: such as minors and older people are more vulnerable than adults, women are more susceptible than men. 4, malnutrition: unreasonable dietary structure, the body’s resistance is reduced. 5, the occurrence of complications: with the development of the disease, lung infection, chronic bronchitis and other complications, greatly increasing the danger to the human body. 6.Literacy and lifestyle: lack of awareness of self-care and self-protection, lack of physical exercise, etc. 7, psychological adverse reactions: such as long-term tension, lack of sleep, anxiety. 8, other diseases: such as renal insufficiency, affecting the autoimmune system. In life and at work, dust exposure should be minimized, while avoiding other susceptibility factors, which also help to reduce the occurrence and development of pneumoconiosis.