Thoracoscopic radical lung cancer surgery is now a routine minimally invasive surgery for lung cancer treatment. Single-port thoracoscopic radical lung cancer surgery has the advantages of less trauma, less pain and more aesthetic appearance. In recent years, with the development of minimally invasive technology, thoracoscopic minimally invasive surgery has become a routine procedure for the treatment of thoracic surgical diseases (lung cancer, esophageal cancer, mediastinal tumor, hand sweating, etc.), and such surgery has been performed in our hospital for many years. Although conventional thoracoscopic surgery generally selects 3-4 operating holes to complete the surgical operation, which has significantly reduced the trauma and satisfied the aesthetic requirements of patients compared with traditional open-chest surgery, it still requires at least 3 or more incisions in the chest to complete the operation. With the improvement of lumpectomy technology, the number of chest openings has also developed from the original 4 holes to 3 holes, or even 2 holes or single hole. In contrast, single-hole (as long as an incision of about 3-4 cm) operation is only used to complete the surgery in one hole (lumpectomy placement is also in the same small hole), which makes the patient less traumatic, less painful after surgery, and more in line with the cosmetic requirements, and is the future direction of minimally invasive surgery development. However, thoracoscopic radical lung cancer surgery with single hole operation has high surgical difficulty and higher technical requirements for the surgeon, which is only carried out in a small number of large general hospitals in China and not reported in the province. Recently, the medical team led by Deputy Chief Physician Fan Junqiang of the Department of Thoracic Surgery completed the first single-port thoracoscopic radical lung cancer surgery (lobectomy + mediastinal lymph node dissection) in China, and the patient recovered well and was discharged from the hospital. At present, the team has performed single-port thoracoscopic surgery for eight patients, seven of whom were radical lung cancer resections (lobectomy or segmental lung resection). According to Fan Junqiang, deputy chief physician of the Second Hospital of Thoracic Surgery, Zhejiang University School of Medicine, not all patients are suitable for single-port thoracoscopic surgery, and proper case selection, good training, and excellent surgical technique are the keys to success or failure. We believe that more patients will benefit from it in the future.