Ankylosing spondylitis and ulcerative colitis can be treated with biological agents. Biological preparation is the use of genetic bioengineering technology to extract highly active peptides, made of immune preparations, can regulate the body’s immunity, can be anti-infective treatment and prevent the disease from continuing to develop, the patient’s prognosis has a better improvement. Ankylosing spondylitis and ulcerative colitis can use biological agents, can play a good therapeutic effect on the disease, biological agents are more specific, faster-acting, and relatively safer, with fewer adverse reactions; in the early stage of the disease application of biologics can reduce the activity of the disease, the prognosis of the disease also plays a good role. Biological agents may interfere with the patient’s immune system, and it is best not to use them if the patient has active infections, tuberculosis and other diseases, and if the patient is allergic to biological agents, they should also be prohibited from using them.