Menopause is an inevitable result of the decline of ovarian function in women, and perimenopause is a natural physiological stage in a woman’s life. Perimenopausal syndrome is a group of post-menopausal symptoms caused by the decline of ovarian function and fluctuation or decline of estrogen levels in women before and after menopause. The normal female menopause is around 50 years old, commonly baking heat, sweating, dizziness and tinnitus, irritability, depression, insomnia, moodiness, urinary frequency and urgency, vaginal dryness, loss of libido, muscle and joint pain. Low back pain, etc. Women in this period often suffer from psychological abnormalities due to the distance between subjective desire and objective reality. Interpersonal relationships, economic problems, family relations, etc. can become important factors that trigger or aggravate the disease, seriously endangering the quality of life and physical and mental health of patients. It usually lasts for 3-5 years, but can last for 10-20 years or even longer. This disease is a common gynecological disease. With the strengthening of China’s economic power, the obvious improvement of living conditions and nutritional status and the progress of medical insurance, the average life expectancy of women in China has been extended to 71 years, and postmenopausal women will continue to live for about 25 years, which accounts for about 1M3 of a woman’s entire life span. the only solution that can fully solve this problem. Especially when the ‘therapeutic window’ is activated, strict control of indications and contraindications, and combined use of estrogen and progestin for women with uterus to treat menopausal syndrome will greatly improve the health of patients. Benefit middle-aged and elderly women. The main purpose of hormone supplementation therapy is to prevent chronic diseases of the elderly due to long-term estrogen deficiency, which has been confirmed by numerous evidence-based medical studies, but is not known to the general public. The International Menopause Society guidelines also recommend the continued use of hormone supplementation to relieve menopausal symptoms, improve urogenital tract atrophy, and prevent bone loss and fractures. In China, both the patients’ families and the menopausal women themselves instinctively reject all treatment with hormones, especially long-term use, due to the traditional fear of hormones. As medical professionals it is their duty to raise their level of awareness and attention to menopausal issues. Therefore, when a woman develops menopausal syndrome she should promptly communicate with her doctor for help and treatment.