Osteoarthritis is a chronic, progressive joint disease in which the combination of mechanical and biological factors leads to an imbalance in the degradation and synthesis of chondrocytes, extracellular matrix, and subchondral matrix. Osteoarthritis is by far the most common chronic disabling disease in the world, and patients with osteoarthritis account for approximately 40% to 60% of degenerative diseases of the osteoarticular system in patients with joint disease. The most commonly affected joints are the hip, knee, hand, and spine joints, and are usually most associated with age. Osteoarthritis of the knee is reported to be common in men until the age of 50, but the incidence of this disease increases rapidly in women after the age of 50. Interestingly, this phenomenon has been called “Menopausal Arthritis” by some researchers, and as populations age, the economic investment in OA will increase and the burden on countries will become heavier. Therefore, in the coming “Bone and Joint Decade”, the study of postmenopausal arthritis will be another hot topic in the prevention and treatment of degenerative arthritis. Although many studies have shown that postmenopausal arthritis is associated with sex hormones, and although their results are often conflicting, studies of the incidence and prevalence of arthritis in postmenopausal women with and without sex hormone replacement therapy (HRT) have revealed that estrogen is a powerful protective agent against postmenopausal arthritis. Recent in vitro and in vivo animal studies have confirmed that chondrocytes reflect estrogen and affect chondrocyte metabolism. spector etal found a higher incidence of knee arthritis in hysterectomized patients through a retrospective study and correlated it with the degree of OA. sowers etal reported that serum estrogen levels17-ß estrogen levels were associated with radiological knee and hand arthritis. In recent years, a large number of literature reports have confirmed that estrogen deficiency increases the risk of osteoarthritis, especially during the high-conversion period, accelerating subchondral bone microfractures or microfractures, and that sex hormone replacement therapy can prevent subchondral bone microfractures and treat osteoarthritis. Osteoarthritis belongs to the category of “bone paralysis” in Chinese medicine. The internal cause of paralysis is the lack of positive energy, and the external cause is the invasion of wind, cold, and dampness, which leads to paralysis due to internal deficiency and external sensation. The liver and kidneys are deficient in blood and tendons, and the kidneys are deficient in essence and bone. The disease mostly occurs after middle age, the “Nei Jing” has “men six or eight, women six or seven, the signs of weakness gradually appear”, “liver qi failure, tendons can not move”, “kidney failure, the shape are extreme” and so on Descriptions indicate that liver and kidney deficiency is a naturally occurring physiological decline, which can lead to weakness of tendons and bones, thus making it easy for wind, cold and dampness to invade and cause this disease. Therefore, liver and kidney deficiency is the root of 0A pathogenesis. In addition, deficiency of liver and kidney, deficiency of qi and blood, weakness of yang, weakness of qi transformation, resulting in qi stagnation and blood stasis. The clear relationship between kidney deficiency and blood stasis has also been confirmed by modern medical research. Cold and dampness paralysis, cold leads, dampness sticks, cold and dampness stagnate the meridians, blocking the flow of qi and blood leads to qi stagnation and blood stasis. Blood stasis directly leads to the loss of nourishment of tendons and bones, which is an important link in the development of osteoarthritis and is also directly related to the treatment effect.