Nowadays, there are many kinds of materials for wrinkle removal by injection, currently commonly used are hyaluronic acid, botulinum toxin, etc., all of which have immediate effect, which is the reason why many people choose wrinkle removal by injection in recent years. In general, the filling of deeper wrinkles (that is, static wrinkles), such as forehead lines, frown lines, etc., can be filled with hyaluronic acid for wrinkle removal. The main purpose of Botox for dynamic wrinkles is to block the connection between nerves and muscles by interfering with and inhibiting the conduction of nerves, so that when doing expressions such as frowning and raising the head, the muscles will not respond accordingly and wrinkles will not be produced naturally. The characteristics of wrinkle removal by injection are no need for incision, no side effects after surgery; precise wrinkle removal by injection, fast results; simple care instructions; short recovery period, does not affect normal work and study after surgery. The effect of one injection can last for about 6 months, and the injection can be repeated in order to maintain the effect. However, the interval between two injections should be 3-6 months. Wrinkle removal by injection is a medical cosmetic project, which involves more drugs and medical materials, and is only a legal product that is allowed to be used clinically after approval by the State Drug Administration.