Hepatitis B minor triple-positive means that the five tests for hepatitis B show positivity for hepatitis B surface antigen (HBsAg), hepatitis B e antibody (anti-HBe) and hepatitis B core antibody (anti-HBc). The severity of hepatitis B minor triplet cannot be generalized. In general, a small triplet of hepatitis B with negative hepatitis B virus DNA indicates that the patient is infected with hepatitis B virus, but the virus replication is in a quiescent state and is less infectious. In this case, compared to the major triplet, it can be said that it is not as serious as the major triplet. However, a long-term minor triplet does not mean that viral replication has stopped or is not infectious. Studies have shown that hepatitis B virus DNA can still be detected in 20% to 50% of patients, possibly in part due to a gene variation in the pre-C region that prevents the formation of hepatitis B e antigen. If hepatitis B virus DNA replication levels are relatively low, they are often easily overlooked, which can lead to exacerbation of the disease. If the hepatitis B virus DNA replication level is relatively high, it indicates that the virus is actively replicating and highly infectious, this kind of hepatitis B small triple Yang needs timely treatment, if not treated in time, the consequences will be more serious, its transformation into liver cirrhosis, liver cancer has a high chance. Therefore, the seriousness of hepatitis B small triple-positive cannot be generalized, but also according to the patient’s hepatitis B five items, hepatitis B virus DNA, liver function and other comprehensive judgment. And patients with small hepatitis B triplets must go to the hospital for regular review to avoid delaying the disease.