Donohue syndrome

  (Dawrau Khan syndrome) [Abstract]: Mostly seen in females, with a peculiar appearance, which becomes apparent after birth, and cannot grow taller, resembling a short leprechaun in an Irish fairy tale, hence the name.  [Alias]: Odd face syndrome; Lepre chaunism syndrome.  [Etiology]: Probably autosomal recessive. The pathology is mainly pituitary gland suspicious color cells, premature maturation of follicles in the ovaries, late maturation of bone marrow, and systemic lymphocytopenia.  [Clinical manifestations]: 1. mental dysplasia, short stature, acanthosis nigricans, and reduced subcutaneous fat.  2. Wide nose, large ears, hirsutism. Widening of orbital spacing.  3. Precocious puberty, hypertrophy of external genitalia and nipples.  4. Large liver, multiple hemangiomas, abnormal endocrine metabolism, low blood glucose, low gonadotropins.  5.17 Increased ketosteroids.  [Treatment]: Symptomatic treatment.