Due to the improvement of living conditions, the compact pace of life and the irregularity of daily eating habits, the trend of patients with gallbladder stones is also increasing. We would like to give a brief introduction to the diagnosis and treatment of gallbladder stones in the hope that the majority of patients will have an understanding of this disease. Gallbladder stones are mainly found in adults, mainly cholesterol stones or cholesterol-based mixed stones, and its causes are complex. Many patients are not used to eating breakfast, which leads to the bile stored in the gallbladder overnight is not thoroughly discharged, and provides convenient conditions for the formation of stones. Therefore, skipping breakfast generally leads to the formation of gallbladder stones. Between 20% and 40% of gallbladder stone patients can be asymptomatic, called resting gallbladder stones. Symptomatic gallbladder stones are mostly manifested as biliary colic or acute and chronic cholecystitis. The main clinical manifestations of gallbladder stones are: most of the patients often show vague distension and discomfort in the upper abdomen or right upper abdomen after eating, especially after greasy food, and fullness may be accompanied by belching and other gastrointestinal symptoms, which are often mistaken for “gastric disease”. Some patients have biliary colic because the stone is located in the neck of gallbladder or obstructed in the neck of gallbladder (i.e., obstructing the outlet of bile excretion of gallbladder), which leads to poor bile excretion after a full meal or eating fatty food, elevated internal pressure of gallbladder, and strong contraction of gallbladder. Some patients have many stones in the gallbladder, some small stones can enter the common bile duct through the cystic duct and obstruct the lower end of the common bile duct and cause obstructive cholangitis, or even pancreatitis in serious cases; a few patients have gallbladder duodenal fistula due to stone compression. In addition, the repeated stimulation of gallbladder stones and inflammation can induce gallbladder carcinoma. The preferred method for the diagnosis of gallbladder stones is ultrasound, which has a correct diagnosis rate of more than 96% and is widely available at low cost. Ultrasound examination is best performed in the early morning when the patient has not eaten, and it is not convenient for ultrasound diagnosis if the gallbladder is emptied after eating. Treatment: The preferred treatment for gallbladder stones is cholecystectomy. For asymptomatic gallbladder stones, immediate cholecystectomy is generally considered unnecessary, but observation and follow-up are needed for regular review; however, gallbladder stones and cholecystitis are causally related to each other. Therefore, doctors usually recommend surgery to remove the gallbladder in patients with gallbladder stones. With the popularization of laparoscopy, most gallbladders can be removed in a minimally invasive way, i.e., through three to four 1cm-sized holes in the abdomen. With the development of technology and further improvement of surgical methods, our department can now successfully complete laparoscopic cholecystectomy (i.e., two-hole and one-hole approaches) by making only two 1-cm incisions or even one 1-cm incision in the abdomen. Of course, laparoscopic cholecystectomy is not feasible for all gallbladders. For patients with severe inflammation and edema of the gallbladder, the hands are prone to bleeding, the anatomical relationship is unclear, and it is easy to lead to bile duct injury, and the chance of turning to open the abdomen is high.