Itchy skin in patients with hepatitis B is not a sign of liver cancer. Liver cancer is usually diagnosed through alpha-fetoprotein test, imaging examination and tissue biopsy. 1. Alpha-fetoprotein test: alpha-fetoprotein is also called tumor marker, if alpha-fetoprotein is higher than the standard level for more than two months, it can be considered as hepatocellular carcinoma. 2. Imaging examination: through liver and gallbladder ultrasound, CT, hepatic angiography and other examination methods, it can find out whether there is any tumor in the liver, and if there is any tumor, further puncture examination is needed. 3. Tissue biopsy: It is possible to diagnose liver cancer through liver puncture biopsy and cytological examination as appropriate. Itchy skin of hepatitis B patients does not mean that it is a precursor of liver cancer, so there is no need to worry too much. However, patients with hepatitis B should be alert to the possibility of abnormal liver function, the best way is to go to the hospital, under the guidance of the doctor to do a systematic examination, and actively cooperate with the doctor on the treatment of hepatitis B, to ensure that the condition will not deteriorate.