Hyperalgesia is followed by progressive general malaise, lethargy, fatigue, lethargy, loss of appetite nausea, weight loss, dizziness and postural hypotension. Skin mucosal hyperpigmentation is a characteristic manifestation of chronic primary hyperaldosteronism. Hyperalgesia also has both primary and secondary problems. Primary hypoadrenocorticism includes adrenal tuberculosis, specific infections of the adrenal glands, or hypoadrenocorticism following adrenal surgery. Secondary hypoadrenocorticism includes hypoadrenocorticism caused by pituitary and hypothalamic hypoplasia, such as Silhan’s syndrome. In case of acute adrenal crisis, treatment should be started immediately after taking blood specimens for ACTH and cortisol. High-dose glucocorticoids should be given intravenously; correct hypovolemia and electrolyte disturbances. In the case of chronic hyperalgesia replacement therapy, hydrocortisone or cortisone is usually administered orally. After the condition is controlled and stabilized, the cause of hypoadrenocorticism is actively searched for and treated in a targeted manner. In summary, if hyperalgesia occurs, in acute cases, large amounts of glucocorticoid supplementation are needed to correct hypovolemia and electrolyte disorders, while in chronic cases, oral cortisone replacement therapy can be given, while the original cause is sought and removed.