Measures to prevent somatic diseases in patients with mental illness include: 1. Personal risk factors and family history assessment: The somatic condition of the patient should be carefully evaluated before medication use, including cardiovascular disease risk factors, height and weight, waist circumference, blood pressure, fasting glucose and fasting lipid levels. The patient’s medical history should be carefully examined and antipsychotic drugs should be carefully selected for patients with high-risk factors such as obesity and family history of diabetes mellitus. 2. Regular monitoring: During treatment, metabolic syndrome and cardiovascular indicators should be monitored regularly. Patients receiving atypical antipsychotics should have their body mass index, waist circumference, lipids, fasting glucose and electrocardiogram checked at the beginning of treatment and every quarter after treatment. For those at high risk for diabetes with positive family history of obesity or abnormal fasting glucose measurement, monitor once a month for the first 3 months of treatment. 3. Rational use of psychiatric medication: If a patient’s weight increases by 5% compared to basal weight or if diabetes worsens further, reconsider the possibility of weight gain caused by their second-generation antipsychotic medication. For those patients who develop diabetes after taking antipsychotics, recommend them to receive specialist treatment. Clozapine should be used with caution when patients have risk factors such as hyperglycemia, abnormal glucose tolerance, a family history of diabetes, obesity, or hyperlipidemia. For elderly patients, we choose drugs to take into account the efficacy of the drug and fully consider the adverse effects of the drug. 4. Establish a good lifestyle: Introduce patients and their guardians to knowledge about the disease, the relationship between antipsychotics and obesity, the effects of smoking and drinking on psychiatric symptoms and physical illness, and the significance of physical exercise on physical health. Patients were advised to avoid high-fat and high-sugar diets, to consume more vegetables and high-fiber grains, and to ask each patient to control the total caloric intake. With the cooperation of the guardians try to make the patients smoke and drink less or quit smoking and alcohol. Strengthen physical exercise, make exercise plans according to each patient’s specific situation, and increase the amount of exercise in a phased and gradual manner. 5. Pharmacological intervention: Some studies reported that the elevated values of body mass, body mass index and insulin resistance in combined metformin treatment were lower than those in combined placebo group, suggesting that metformin may be related to reducing the increase in body mass and disorders of glucose metabolism caused by antipsychotic drugs.