Rathke’s cyst is a benign epithelial cyst of Rathke’s bursa origin, a dilutable remnant that appears at 3-4 weeks during embryonic development. Normally, Rathke’s bursa closes in adulthood, otherwise epithelial cells covering the middle lobe secrete mucus to fill the Rathke’s bursa and continue to expand, forming Rathke’s cysts between the anterior and posterior pituitary lobes. Most Rathke’s cysts are small and when they are more than one centimeter in diameter, they can compress the pituitary stalk, adenohypophysis and hypothalamus and produce symptoms. The main symptoms are enlargement of the cyst and compression of adjacent tissues, manifested by headaches, visual disturbances, and endocrine changes. Patients with asymptomatic Rathke’s cysts have the option of follow-up observation, and if symptoms are severe, transnasal surgery is the treatment of choice.