There are two major classes of antiviral drugs that are currently recognized as having been marketed in China: nucleoside (acid) class and interferon class. Both drugs can inhibit the replication of hepatitis B virus to varying degrees, but each has its own advantages and disadvantages. The nucleoside (acid) class of antiviral drugs is universally recognized by doctors and patients as soon as they hit the market because of its rapid virus inhibition, strong antiviral effect, the convenience of taking only one capsule orally, usually one capsule a day, minimal adverse effects, and relatively low cost. However, its disadvantages are also more prominent, such as the need for long-term use, i.e., no fixed course of treatment, and the possibility of drug resistance, which should also attract sufficient attention. For friends who have decided to choose or are taking nucleoside (acid) class antiviral drugs for hepatitis B patients, I have the following points to remind you to pay attention to: 1. Take it regularly every day. That is, it is best to take a fixed time every day, the recommended time: every day before bedtime. The advantages: one is to make a habit, will not forget; two, such as taking entecavir need to fasting. 2, do not stop using on their own. This can cause viral rebound, increased liver damage, and even liver failure can occur. This happens mostly when the patient takes it after the effect, laboratory tests HBVDNA negative, liver function is normal, thinking that the treatment can be stopped. Sometimes, there are reasons for the doctor, such as not clearly explained to the patient or the doctor itself is less experienced. 3, regular monitoring to prevent and early detection of drug resistance. Therefore, you should see an experienced doctor to work out the appropriate follow-up time or adjust your treatment in time according to your response to drugs, early or late, side effects and the resistance rate of the nucleoside (acid) antiviral drugs you are taking. 4. Pay attention to adverse reactions. In general, nucleoside (acid) class antiviral drugs taken orally are well tolerated by patients and have no significant discomfort. Just to remind you: taking adefovir should pay attention to regular review of renal function; taking timifedine regular review of creatine kinase (CK), although the incidence of this side effect is not high. 5. For hepatitis B patients taking nucleoside (acid) antiviral drugs during their childbearing years, they should consult an experienced doctor to select or adjust drugs that have little effect on the fetus according to your specific situation.