1, sternal pressure pain sternal pressure pain is a symptom unique to leukemia, often persistent, accompanied by bone and joint pain, mostly seen in children. 2, fever body temperature up to 38 ℃ ~ 39 ℃, generalized aches and pains. This fever is due to a decrease in mature granulocytes in the blood and decreased immune function combined with infections, such as pharyngitis, tonsillitis, pneumonia, pyelonephritis, etc., and can be accompanied by inflammation and ulceration of the eyes, ears, mouth, nose, oropharyngeal cavity, and patients often feel tired.3. Infectious agents are more common with bacteria. The risk of viral infections is rare but dangerous and should be taken into account.4. Bleeding can occur throughout the body, with skin petechiae, petechiae, gum bleeding and nasal bleeding being the most common, as well as retinal and ear bleeding and internal bleeding in the skull, gastrointestinal tract, respiratory tract and other internal organs, often causing progressive anemia.5. In a few cases, myelodysplastic syndrome (MDS) may first appear months or years before diagnosis, and then develop into leukemia. Patients often have symptoms such as weakness, pallor, palpitations, shortness of breath, and edema of the lower extremities.