The main treatment for H. pylori is quadruple drug therapy, i.e., 2 antibiotics, 1 bismuth agent and 1 proton pump inhibitor for 10-14 days. H. pylori is a common cause of chronic gastritis, gastric ulcer, duodenal ulcer, and reflux esophagitis, and can be treated with quadruple two-week therapy. Quadruple therapy consists of three main classes of drugs, two antibiotics, one bismuth agent, and one proton pump inhibitor. Common combinations used in quadruple therapy are omeprazole + bismuth potassium citrate + amoxicillin + clarithromycin capsules. The choice of antibiotic should be based on local antibiotic resistance, with quinolones such as levofloxacin commonly used or tinidazole in some areas. Eradication of H. pylori should be carried out according to the requirements of gastroenterologists, scientific and regular taking of drugs for two weeks, most patients can get better treatment. Tracking anti-H. pylori efficacy should be reviewed in an outpatient clinic at least four weeks after stopping the medication. H. pylori examination includes two categories: invasive route and non-invasive route; invasive route is mainly rapid urease test after taking tissues from gastroscope; non-invasive examination commonly used carbon 13 or carbon 14 breath test. Fecal antigen testing is also available. Meal sharing and the use of communal chopsticks and spoons are recommended to help prevent H. pylori infection.