Staging of membranous nephropathy

  Stage I of membranous nephropathy: normal glomerular capillaries under light microscopy, scattered or regularly distributed deposits of small immune complex-like electron-dense material in the interstitial region of the glomerular basement membrane and epithelial cells under electron microscopy.  Stage II: The glomerular capillaries were unevenly thickened to form “pegs” under light microscopy. Electron microscopy revealed the presence of electron-dense deposits under the epithelial cells.  Stage III: Light microscopy shows newly formed basement membrane-like material encircling the deposits, forming a network or chain-like manifestation. Electron-dense material deposited within the basement membrane or under the epithelium under electron microscopy.  Stage IV: Significant thickening of the basement membrane under light microscopy. Electron density of the deposit is lost under electron microscopy, and irregular electron translucent areas appear in the irregularly thickened basement membrane.