Hepatitis B virus levels of less than 50 copies per milliliter are normal. Normally, the Hepatitis B virus DNA replication number is less than 1000 copies per milliliter, below this value indicates that the number of Hepatitis B virus replication in the body is very low. Before testing for Hepatitis B DNA replication number, it is necessary to determine whether the patient is a Hepatitis B carrier, such as Hepatitis B triple positive, Hepatitis B minor triple positive, and also need to evaluate the patient’s liver ultrasound, to determine whether there is any fibrosis or cirrhosis of the liver, and to evaluate the function of the liver, to determine whether there is any increase in the level of aminotransferases. For hepatitis B virus replication number is not high, but if there is a family history of liver malignancy or cirrhosis, it is necessary to take oral antiviral medication in a timely manner. For patients with hepatitis B, it is recommended that they can consult the Department of Infectious Diseases of regular hospitals, and not to be neglected in order to avoid delaying their condition.