Blisters on the feet can be poked and prodded under sterile conditions, but it is best not to do so when there are no special circumstances. If the blisters are relatively large and have affected daily life, you can choose to poke the blisters, but you should pay attention to only use a sterile needle to pick the blisters, do not damage the epidermis of the blisters, and the whole process follow aseptic operation, in order to avoid infection. The blister should be sterilized first, punctured with a sterile needle, squeezed out with a sterile cotton swab, sterilized again, and finally bandaged with sterile gauze or band-aid. It is recommended that smaller blisters should be left unpunctured as much as possible without affecting daily life, and wait for them to absorb on their own, so as to better avoid infection. Even if the blister has been pricked under aseptic operation, the outer skin should not be damaged, as it can also play a protective role against infection, and should be disinfected frequently to keep the affected area in a dry and hygienic state. Blisters on the feet are recommended to go to the hospital in a timely manner, do not poke them by yourself, the specific should be operated by a professional physician.