Contraindications to interferon include relative and absolute contraindications. Absolute contraindications: pregnancy, history of psychiatric disorders (e.g., major depression), uncontrolled epilepsy, unabated alcohol and/or drug abuse, uncontrolled autoimmune diseases, decompensated cirrhosis, symptomatic heart disease. Zhao Wenxia, Department of Spleen, Gastrointestinal, Hepatobiliary Diseases, The First Affiliated Hospital of Henan College of Traditional Chinese Medicine, relative contraindications (use of interferon may aggravate the original disease): thyroid disease, retinopathy, psoriasis, previous history of depression, uncontrolled hypertension, diabetes mellitus, pre-treatment neutrophil count <1.0×109/L and/or platelet count <50×109/L, total bilirubin >51μmol/L.