Interferon has been used for 20 years to treat viral hepatitis and has been one of the most commonly used antiviral drugs because of its dual antiviral and immunomodulatory effects and low relapse rate after obtaining efficacy. However, interferon also has some adverse effects, such as flu-like syndrome, peripheral blood leukocyte and platelet decline, hair loss, mental abnormalities, induction of potential autoimmune disease manifestation, cardiac arrhythmia, thyroid function abnormalities, etc. Therefore, the following indicators should be monitored regularly during interferon therapy according to the condition: blood routine, liver and kidney function, hepatitis B five, HBV DNA quantification, blood glucose, etc., and when necessary If necessary, ECG, glycosylated hemoglobin, thyroid function, autoantibodies and mental status assessment can be done to ensure the safety of the medication.