Patients with skin peeling on hands may be caused by fungal infection, sweat herpes, keratolysis, etc. Patients can improve their condition through medication and surgery. 1. Fungal infection: when the patient’s hands are infected by fungal infection caused by tinea cruris, it can be manifested as peeling skin, itching and other symptoms, the patient can use fluconazole, itraconazole, terbinafine, naftifine and other drugs under the guidance of the doctor for treatment. 2. Sweat herpes: Sweat herpes may cause sweating, peeling, burning and itching of the hands and feet, etc. Patients can take oral hormonal drugs, such as prednisone, etc.; antihistamines, such as benadryl, loratadine, etc., and can also be applied locally with ketamine ointment, pimecrolimus ointment, glycerol lotion, etc. for treatment. 3. Keratolysis: Keratolysis is a superficial exfoliative dermatosis of the keratin layer of the palm and plantar area, and patients can use coal tar ointment, Vitamin A acid cream, salicylic acid ointment, petroleum jelly ointment and other medications under the guidance of the doctor for local treatment. It is recommended that patients strictly follow the doctor’s instructions to use medication, do not change the dose of drugs or abuse drugs, avoid scratching in life, to prevent rupture caused by infection.