How to manage clinical recurrence of prostate cancer after radical prostatectomy?

  If a patient is judged to have developed clinical recurrence of prostate cancer, it should be determined whether the recurrence is local, regional lymph node metastasis, or distant metastasis. The choice of treatment for patients with biochemical recurrence after radical surgery is controversial, and options include watchful waiting, salvage radiotherapy, and endocrine therapy.  For patients with biochemical recurrence and no clear indication of clinical recurrence, a comprehensive analysis based on relevant examination results should be performed to predict whether the tumor is a local recurrence or extensive metastasis. For those with high possibility of local recurrence, watchful waiting treatment or salvage radiotherapy can be used, and for those with high possibility of extensive metastasis, endocrine therapy can be used. If clinical local recurrence has been clearly established, salvage radiotherapy or other local treatment should be chosen. If clinical local recurrence has been established, salvage radiotherapy or other local treatment should be chosen, and if clinical extensive metastasis has been established, endocrine treatment should be used.