Problems faced by people with advanced reproductive age – declining fertility at advanced age Advanced pregnant women are those who are ≥35 years old at the time of delivery, and because women’s fertility and the organism conditions affecting fertility are in a state of decline after 35 years of age, advanced women are subject to the combined long-term effects of various risk factors such as biological, environmental and psychological behavioral factors Therefore, it is very important to provide targeted preconception and pregnancy care according to the characteristics of women of advanced age. Reproductive aging inevitably occurs with advancing age, especially in women. The Fertility Guidelines published by the UK Human Fertilization and Embryology Authority state that fertility in women at age 35 is only 50% of what it was at age 25, dropping to 50% of what it was at age 35 by age 40. What is more common in clinical practice is that those who reproduce have often had multiple conceptions but given abortions, the presence of multiple uterine operations resulting in endometrial damage, endometritis, and even more with age may endometrial polyps or submucosal fibroids, adenomyosis and other diseases can lead to embryo implantation failure and miscarriage. However, advanced age is not equal to infertility. It is recommended that couples who are advanced in age and preparing for their second child should first try to conceive naturally, and if they do not have a pregnancy within one year of trying to conceive naturally, they meet the diagnostic criteria for infertility and should consider using assisted reproductive technology. It is recommended that women over 40 years of age, while taking measures to prepare for pregnancy, can also go to the hospital for fertility assessment such as ovarian function and decide whether to undergo assisted reproductive technology based on the results of the assessment. If the first child was conceived successfully with the help of assisted reproductive technology, assisted reproductive technology is preferred for the second child.