I. Concept.
Bacterial translocation from the intestine
The process by which bacteria in the intestine enter the liver, spleen, and lymph nodes to the systemic circulation via the portal vein due to impairment of intestinal barrier function.
Enteric-derived endotoxemia
Endotoxemia is caused by the growth and multiplication of bacteria in the intestine, producing large amounts of endotoxin, which enter the blood through the intestinal mucosa.
II. Causes.
Various causes of intestinal barrier function damage.
1. Hypoxia. Such as shock, cardiopulmonary disorders, etc.
2. Increased intestinal pressure. Such as intestinal obstruction, intestinal anesthesia after pancreatitis, etc.
3.Immune hypofunction. Such as MODS or MSOF.
4.Bacterial or endotoxin accumulation in the intestine. Such as long-term non-defecation.
5, dysbiosis. Improper application of antibiotics.
6, other: poisoning, etc.
Third, clinical manifestations.
The performance of the primary disease + systemic infection symptoms, such as bacteremia, sepsis, toxemia, etc.
Specific manifestations are high fever, chills, and systemic failure.
IV. Laboratory tests.
1. Increased WBC and neutrophilia.
2, anemia
3. Blood culture can be used to detect pathogenic bacteria.
4, check the endotoxin content in the blood.
V. Prevention and control.
1, prevention: once the cause of the disease exists, drug treatment should be given.
2, treatment: mainly take a combination of Chinese and Western medicine treatment.
(Western medicine is to raise the soup to stop the boiling, Chinese medicine is the axe bottom.)
(a) Western medicine treatment
(1) Treatment of the primary disease
(2) Control the infection and apply antibiotics.
(3) Protect the vital organs.
(4) Increase the immunity of the body.
(II) Chinese medicine treatment
(1) Tongli attack: the six internal organs are used to pass
(2) Clearing heat and detoxifying toxins: double flowers and forsythia.
(3) Invigorate blood circulation and resolve blood stasis. Peach kernel, safflower, red peony
(4) Tonifying Qi and nourishing Blood. Astragalus, Angelica, Radix Rehmanniae, Ginseng.