Condyloma acuminatum is an epidermal neoplastic growth in the genital, perineal and anal areas caused by human papilloma virus infection. It is the most common sexually transmitted disease worldwide, and recurrent attacks are one of the characteristics of the disease, especially urethral condyloma acuminatum is difficult to treat. In the past, ordinary laser treatment was generally used, but the treatment was painful for the patient, slow to recover after treatment, and easy to produce urethral scarring leading to stricture. In China, condyloma acuminata accounts for 25-30% of patients with STDs, and hundreds of thousands of new cases are added each year, a common sexually transmitted disease. Condyloma acuminatum occurs in the external genitalia and perianal skin mucosa, and it is now clear that HPV infection is associated with the development of genital tumors, especially cervical cancer in women. Early and thorough treatment of condyloma acuminata is an important means of preventing cervical cancer. Photodynamic therapy (PDT) is a new treatment method that is increasingly used this year to selectively destroy target tissues through photodynamic reactions by combining photosensitizers and corresponding light sources. This treatment has few side effects and a high cure rate. The most widely used in dermatology is the photodynamic therapy with topical ALA, which has achieved good results in the treatment of condyloma acuminata, heliokeratosis, superficial basal cell carcinoma and Bowen’s disease with no significant side effects. The principle is that local application of photosensitizer, due to different absorption and metabolism rate, will accumulate a high concentration in the target tissue (such as tumor) after a certain period of time, and then irradiate the target tissue with light source of appropriate wavelength to produce a large amount of monomorphic oxygen in the target tissue through a series of photochemical reactions and release fluorescence at the same time. The cytotoxic effect of monomorphic oxygen will cause the target tissue to die and cause the rash to subside. Currently, the photosensitizer of ALA, which is widely used in dermatology, accumulates at a high concentration in the hyperplastic tissue 3h-6h after local application. ALA is metabolized in cells to produce protoporphyrin 9. PpIX has strong photosensitivity and produces monomorphic oxygen after red light irradiation.