The earlier the age of menarche, the earlier the decline of ovarian function. Secondly, premature ovarian failure is related to fertility status. The older the age of first pregnancy, the earlier the ovarian decline; the longer the breastfeeding time, the later the ovarian decline; the longer the oral contraceptive pill, the later the ovarian decline. Third, premature ovarian failure and lifestyle habits, lack of exercise, irregular life, smoking and alcohol stimulation of women, ovarian function decline early; and adhere to a healthy diet, regular life, adhere to the exercise of women ovarian function decline late. Fourth, the compression of shape-shifting underwear leads to restricted ovarian development and impaired function, making it easy for premature aging to occur. Especially teenage girls wear tight-fitting clothes for a long time, which not only affects development, but also induces diseases such as breast enlargement or cysts. Fifth, the fast pace of life and psychological stress can also lead to premature ovarian failure and early menopausal symptoms in women. The principles are: 1. High-dose intermittent medication is better than low-dose continuous medication; the former means about 1 week of medication per course, with an interval of about 3-4 weeks, which can achieve effective anti-tumor effect and also help the body to eliminate toxicity and restore immune function. 2. Combination chemotherapy is more effective than single chemotherapy: in recent times, there is a tendency to combine drugs, but it should be noted that the toxic reaction of combination chemotherapy is heavier. 3, according to the drug sensitivity test, the choice of sensitive chemotherapy drugs, can prolong the survival time of patients. 4, according to the tissue type to develop different chemotherapy regimens.