Drug side effects vary from person to person, zolpidem tartrate and zopiclone tablets have less side effects, it is not possible to scientifically compare the size of the side effects of the two, it is recommended to choose the right drug for treatment under the guidance of a professional doctor and follow the doctor’s instructions for the correct use of the drug, to minimize the side effects of the drug. These two drugs are currently commonly used in clinical sedative hypnotic drugs, both belong to the non-benzodiazepine drugs. The half-life of zolpidem tartrate is relatively short, ranging from 0.5 hours to 3.5 hours; the half-life of zopiclone is about 5 hours. Both are also cleared from the body at different times; most of the drug is essentially eliminated from the body 2 to 10 hours after taking zolpidem; zopiclone takes 15 hours. Zolpidem tartrate is primarily used for temporary and induced insomnia and is taken for a short period of time. Adverse effects such as edema, dizziness, dyspepsia, and fatigue may occur; zopiclone is a broad-spectrum sleeping pill that can be used for normal insomnia and can be taken for long periods of time. Adverse reactions include drowsiness, bitter mouth, dry mouth, and muscle weakness. Zolpidem tartrate is contraindicated in people who are allergic to this product and the ingredients contained in it, people with severe respiratory insufficiency, patients with sleep apnea, etc.; Zopiclone is contraindicated in people who are allergic to this product and the ingredients contained in it, patients with uncompensated respiratory insufficiency, patients with myasthenia gravis, etc. Patients need to take these two drugs, should be used under the guidance of a professional doctor, avoid blind use of drugs, and strictly follow the doctor’s instructions.