A low albumin to globulin ratio is when the ratio of albumin to globulin is below the normal range. Albumin and globulin are the two most important plasma proteins in the body, they have different structures and perform different functions, and their values must be maintained within the normal range, i.e. the ratio of albumin to globulin is also a relatively fixed value. The most common reason for a decrease in the ratio of albumin to globulin is a decrease in the amount of albumin or an increase in the concentration of globulin, for example, in patients with chronic kidney disease due to the loss of albumin from glomerular filtration, there is a decrease in the albumin-to-globulin ratio. Patients with chronic liver disease also have a low albumin-to-globulin ratio due to decreased albumin production by the liver, resulting in a lower albumin concentration. A low white globule ratio can also occur in elevated globulin concentrations, such as in various autoimmune diseases, such as rheumatoid arthritis, systemic lupus erythematosus, and multiple myeloma, due to an abnormally high globulin concentration.