Generally, more than three episodes of hypoglycemia in one year can be considered as frequent episodes. These patients should promptly find out the cause of hypoglycemia to minimize the episodes of hypoglycemia. Hypoglycemic episodes are most common in diabetic patients. Hypoglycemia can occur when diabetic patients take oral hypoglycemic drugs or use insulin and do not eat in time or eat too little, or when diabetic patients suddenly perform heavy physical work or exercise too much, resulting in excessive sugar consumption. In addition, hypoglycemic episodes can be caused by severe malignancy, liver failure, heart failure, severe malnutrition, and hyperalgesia. In patients with islet cell tumors, hypoglycemia may occur due to continuous insulin secretion from pancreatic beta cells, but the incidence of such cases is low. Some patients with hyperinsulinism, such as obese patients, lead to hypertrophy of adipocytes and metabolites that can easily make skeletal muscle isletal cells resistant, thus triggering hyperinsulinemia, and these patients are also prone to hypoglycemia. For diabetic patients, the risk of hypoglycemic episodes is higher than that of hyperglycemic episodes. After hypoglycemic episodes, it is easy to cause cardiovascular complications, such as sudden cardiac death, cardiogenic shock and cerebrovascular accident. The more frequent the hypoglycemic episodes, the more serious the damage occurred in cardiovascular and cerebrovascular. Hypoglycemic episodes lead to a lack of energy in the central nervous system of the brain, and the patient may experience hypoglycemic coma. If the hypoglycemic coma is not corrected for 6 hours, it can easily lead to vegetation and even endanger the patient’s life. Therefore, if hypoglycemia occurs frequently, you should go to the hospital in time to clarify the cause through biochemical examination, quantitative glucose test, fingertip glucose and other examinations, and treat the cause to avoid serious adverse consequences.