Granny Shen has had diabetes for more than ten years, the last few years, Granny Shen listened to the advertisement to buy some gold bitter melon capsules to eat, recently due to often feel uncomfortable heart, to the cardiology department hospitalization, hospitalization process, in the middle of the night, Granny Shen had a serious hypoglycemia, when checking the blood glucose is only 1.8 mmol / L, the results of the next morning, Granny Shen due to a large-scale heart infarction died of death and passed away. Doctors feel sorry for Mrs. Shen at the same time, but also thinking about whether there is any correlation between hypoglycemia and Mrs. Shen’s heart attack? Wuhan Union Medical College Hospital Endocrinology Department Chen LuLu many diabetic friends have been fully aware of the dangers of high blood sugar and the importance of controlling blood sugar, but sometimes ignore the harm of hypoglycemia, in fact, the harm of hypoglycemia is no less than high blood sugar, the famous diabetes expert Professor Krier once described hypoglycemia in this way: “a severe hypoglycemia or the resulting cardiovascular events may offset the maintenance of blood sugar for a lifetime, but also to maintain blood glucose. A single severe hypoglycemic or cardiovascular event can negate the benefits of maintaining blood glucose in the normal range for a lifetime.” This is indeed true. In the case of Mrs. Shen, hypoglycemia was not blamed for her death, and it is not uncommon to find clinical examples of serious adverse outcomes due to hypoglycemia in Mrs. Shen’s case. In recent years, the results of large-scale clinical studies at home and abroad have revealed to us all the evils of hypoglycemia, patients with hypoglycemia have a 65% higher risk of heart attack within two weeks than those without hypoglycemia, and patients with severe hypoglycemia have a much higher chance of having a heart attack and dying than those without severe hypoglycemia. For normal people, blood glucose below 3.0 mmol/L is called hypoglycemia, while for diabetic patients, as long as the blood glucose is below 3.9 mmol/L, it is a hypoglycemic event, and if the hypoglycemia is accompanied by impaired consciousness, it is clinically called “severe hypoglycemia”. Due to the longer fasting time at night, coupled with the fall, the night time is longer, patients are prone to hypoglycemia at night and in the early morning, therefore, “hypoglycemia” accompanied by diabetic patients overnight has occurred time and again. So, how can diabetic patients avoid nighttime hypoglycemia, especially severe hypoglycemic episodes? First of all, the rational use of hypoglycemic drugs, whether insulin or oral hypoglycemic drugs, the use of drugs is the main reason for the occurrence of hypoglycemia is important, diabetic patients should regularly monitor blood glucose, according to the condition of the timely adjustment of the drug dose. Currently on the market, many claim to be able to “cure” diabetes “traditional Chinese medicine”, by many diabetic patients favor, in fact, these “traditional Chinese medicine” is often mixed with hypoglycemic western medicine, and the majority of glibenclamide. In fact, these “traditional Chinese medicines” are often mixed with sugar-lowering western medicines, and most of them are glibenclamide, which is often called “eugenol” in the past. The effect of this medicine is very strong in lowering sugar, but due to the serious side effects of hypoglycemia, it has been seldom used in clinics nowadays, and we speculate that the cause of the hypoglycemia of Mrs. Shen is related to her oral intake of “Golden Bitter Gourd capsules”. “We believe that the cause of her hypoglycemia is inextricably linked to the presence of glibenclamide in the capsule. Secondly, to develop good habits, regular life, diet regular meals, easy to occur hypoglycemia time for the meal system, even out part of the amount of staple food for additional meals, if the amount of meals should be reduced accordingly to reduce the dose of medication. Again, exercise in moderation, if there are diabetic friends have the habit of going out after dinner, the amount of exercise should not be too large, exercise time should not be too long, at the same time, pay attention to monitoring the blood glucose before going to bed, and make the necessary meals, or reduce the dose of medication in the dinner time. Finally, drinking alcohol, especially on an empty stomach is also a major culprit in causing hypoglycemia, diabetic patients should minimize alcohol consumption. In particular, it is suggested that the elderly, emaciated, patients with a long course of disease and renal insufficiency are more prone to hypoglycemia, and for these patients, it is even more important to be cautious in lowering blood glucose, and controlling blood glucose under the premise of avoiding the risk of hypoglycemia.