First, no antibody production (1) Some people have late antibody production, which is called delayed response. For this, 1 or 2 additional doses can be given, or the vaccine can be revaccinated and the dose increased appropriately. (2) Immunization programs of 0, 1, 2, or 12 months may be used. (3) Combine a small dose of interleukin-2 with hepatitis B vaccination. (4) BCG vaccine or cowpox vaccine can increase the immune response to hepatitis B vaccine and can be used together. Second, how long to be vaccinated again The level of antibodies produced after hepatitis B vaccination gradually decreases with time. In general, 97% of people can detect surface antibodies one month after 3 injections of the vaccine; in the second year, they remain at this level; in the third year, they drop to about 74%, and the antibody titer also decreases. The need for revaccination is mainly determined after the titer of hepatitis B surface antibody is measured, and the decision of when to revaccinate is made. Those with hepatitis B surface antibody titers less than or equal to 10 IU/ml should be vaccinated within six months. Antibody titers greater than 10 IU/mL can be revaccinated within 6 years. Many medical practitioners in China recommend a booster within 3 years after immunization as a good idea. Thirdly, simultaneous use with other vaccines Hepatitis B vaccine can be given at the same time as the influenza vaccine, BCG vaccine, Bacille Calmette-Guérin vaccine, polio vaccine and cerebral B vaccine, and the vaccination procedure is carried out in the order required by the planned immunization. However, it is best not to use hepatitis B vaccine and measles vaccine at the same time. Fourth, how to vaccinate for accidental exposure to the virus (1) For contacts who have not been vaccinated, first inject hepatitis B immunoglobulin (within 24 hours) and vaccinate with hepatitis B vaccine at different sites at the same time. (2) If the contact has been vaccinated but not fully immunized, the full immunization should be made up according to the hepatitis B vaccine immunization procedure after the hepatitis B immune globulin injection. (3) Contacts who have been vaccinated and have developed hepatitis B surface antibodies should be vaccinated according to their antibody levels. If the level of hepatitis B surface antibody is sufficient, there is no need to deal with it; if the level is not sufficient, a booster shot of vaccine should be given; if there is no response to the initial immunization, one shot each of hepatitis B immunoglobulin and hepatitis B vaccine should be given as soon as possible. Fifthly, people who should not receive hepatitis B vaccine are prohibited to have serum disease, bronchial asthma, allergic urticaria and allergy to some drugs such as penicillin and sulfonamide. Newborns with low birth weight, premature birth, caesarean section and other abnormal births are not suitable for hepatitis B vaccination for the time being. Although hepatitis B vaccine is not harmful to these newborns, it is better to postpone the vaccination because their own physical condition is prone to coupling events.