Many drugs can aggravate or induce psoriasis. The following drugs have been reported in the literature to be associated with the onset and aggravation of psoriasis: beta-blockers, lithium, anti-malarial drugs, and drugs in the hypoglycemic class (e.g., euglycemia). Calcium channel blockers, such as nifedipine, nisoldipine, isoptin, thioprogesterone, mercaptopropionic acid. Iodides, terbinafine, memantine, tetracycline, chloroquine, acetazolamide can also induce psoriasis. Some lipid-lowering drugs, such as gemfibrozil, can also aggravate psoriasis. In addition, coal tar and salicylic acid drugs can cause psoriasis to rebound. It is well known that long-term use of corticosteroids in psoriasis patients can lead to rebound of the disease, and they are drugs used with caution in psoriasis patients. Recently, many recombinant human cytokines have been used for clinical treatment, and the application of granulocyte clone-stimulating factor, interleukin, α-interferon, and β-interferon to induce psoriasis has been reported, which deserves the attention of dermatology clinicians. Finally, it has been reported that metronidazole may aggravate psoriasis and is also a drug that should be used with caution by psoriasis patients.