Hepatitis B major triple-positive means that the five tests for hepatitis B show three positives for hepatitis B surface antigen (HBsAg), hepatitis B e antigen (HBeAg), and hepatitis B core antibody (anti-HBC), while hepatitis B minor triple-positive means three positives for hepatitis B surface antigen, hepatitis B e antibody (anti-HBe), and hepatitis B core antibody. Therefore, the main difference between the two is that major triplets are positive for hepatitis B e antigen, while minor triplets are positive for hepatitis B e antibody. Hepatitis B e antigen positive: Hepatitis B e antigen has a good correlation with hepatitis B virus DNA. The presence of hepatitis B e antigen indicates active viral replication and strong infectiousness, indicating that the patient is in a high infection and low response period. Hepatitis B e antibody positive: indicates that viral replication is mostly in a quiescent state and the infectiousness is reduced, but some patients have viral replication and hepatitis activity. However, long-term positive hepatitis B e antibody does not mean that viral replication has stopped or is not infectious. As mentioned above, the main difference between major and minor triplets is that major triplets have active hepatitis B virus replication and are highly contagious, while minor triplets have hepatitis B virus replication in a quiescent state and are less contagious. However, both major and minor triplets indicate that the patient is infected with the hepatitis B virus, and both need to be treated with caution, reviewed regularly and treated actively.