Hepatitis B major triple-positive refers to patients with positive surface antigen, e antigen and core antibody in the five tests of hepatitis B. If the patient’s liver function is basically normal and there are no uncomfortable symptoms, he/she can receive the vaccine normally and the hepatitis B virus usually does not affect the vaccine. For patients with acute hepatitis or acute attacks of chronic hepatitis with significant abnormal liver function, it is recommended that vaccination with the New Crown vaccine be withheld. It is recommended to wait for 1-3 months after the liver function has returned to normal, or after evaluation by a professional physician, before administering the New Crown vaccine. Referring to the “Quick Guide to New Coronavirus Vaccination for Patients with Chronic Liver Disease, Liver Malignancy and Liver Transplantation” prepared by the Hepatology Branch of the Chinese Medical Association, chronic hepatitis B patients who are receiving medication and whose condition is well controlled can receive the New Coronavirus vaccine, and none of the medications should be discontinued during the vaccination period (including antiviral drugs for hepatitis B and C, etc.). For those who are receiving interferon therapy, the New Crown vaccination should be given 2-3 days apart from the interferon injection. Patients with hepatitis B major third-positive who can receive the New Crown vaccine normally need to be observed at the vaccination site for half an hour after vaccination to prevent other adverse reactions, such as nausea, vomiting, weakness, generalized aches and pains. If adverse reactions are found, you can promptly go to the hospital for liver biochemistry and other related tests to clarify whether they are caused by hepatitis B or by adverse reactions after New Crown vaccination, and receive appropriate treatment.