Hepatitis B major tri-positive is a kind of chronic hepatitis B virus infection. Only if it is detected early, the patient is in good health and actively cooperates with the doctor, simple hepatitis B major tri-positive can achieve clinical cure. However, clinically many patients fail to be detected and treated early because they have no obvious clinical symptoms, and by the time they are found, they already have abnormal liver function, or even cirrhosis and ascites. In this case, it is very difficult to cure the disease, and can only prolong the life of patients and improve their quality of life by improving their symptoms and inhibiting the development of the disease as much as possible. The initial detection of hepatitis B major tri-positive also requires further examination of hepatitis B virus quantification, liver function, liver ultrasound and other laboratory tests and examinations, timely antiviral and immunomodulatory treatment, due to the side effects of treatment, generally older than 30 years old, accompanied by high viral quantification of patients recommended to give treatment; age less than 30 years old, normal liver function, normal hepatitis B virus quantification, normal liver ultrasound, no liver cancer, cirrhosis Those with family history can be reviewed in 3-6 months. Without cirrhosis, patients with hepatitis B major tri-positive treatment HBeAg turned negative, e antibody positive, detection of viral quantification below the upper limit of normal, and receive at least 12 months of antiviral consolidation therapy, and regular testing indicators are at normal levels, is considered clinically cured, but due to the high rate of hepatitis B variation, oral drug cycle is long, involving patient cooperation, medical costs, adverse drug reactions and many other issues waiting The treatment of hepatitis B is a long way to go. Therefore, whether hepatitis B is clinically curable or not is related to early detection, early diagnosis, early treatment and the patient’s physical condition, therefore, once hepatitis B is detected, patients and their families need to actively cooperate with the treatment in order to achieve better treatment results.