Quadrivalent refers to the quadrivalent cervical cancer vaccine. There is no claim that it is difficult to get pregnant after taking the quadrivalent cervical cancer vaccine, and there is no such study in the clinic. Quadrivalent cervical cancer vaccine is a kind of inactivated vaccine, which mainly stimulates the immune cells in the body to produce antibodies through the reaction, thus preventing some high-risk and low-risk human papillomavirus infections. Clinical studies have shown that the quadrivalent cervical cancer vaccine does not affect pregnancy, and pregnancy does not need to be terminated during the vaccination period. There are more reasons to affect pregnancy, such as: tubal abnormalities, sperm quality abnormalities, etc., generally do not consider the vaccine factor. Therefore, if a woman has difficulty in getting pregnant after taking the cervical cancer vaccine, it is recommended that she should consult a doctor in time. After the doctor’s consultation and taking into account the woman’s specific situation, she should choose the appropriate examination program, and according to the results of the examination to clarify the cause of the disease and then target the treatment.