There is no exact rule that adverse reactions will occur within a few hours after intravenous infusion of cephalosporin, and they are usually related to the individual’s constitution, and can occur in as little as ten seconds or in 0.5-1 hour or longer. Cephalosporin is the general name of cephalosporin antibacterial drugs, and its adverse reactions mainly include nausea, vomiting, diarrhea and abdominal discomfort, skin rash, drug fever and other allergic symptoms, and in severe cases, anaphylaxis may occur. Some patients may also experience neurological reactions, such as dizziness, tinnitus and convulsions. A common adverse reaction to cephalosporin infusion is allergy, which generally occurs more rapidly. Some patients can develop symptoms such as skin erythema or urticaria in ten seconds, and in serious cases, laryngeal edema with dyspnea and suffocation, and even anaphylactic shock. If adverse reactions occur during the infusion process, continue drug administration should be stopped promptly, and tracheotomy should be performed if necessary to keep the airway open. Cephalosporin infusion must be prohibited before and after drinking alcohol to prevent shock, syncope and even death in serious cases. Therefore, infusion should be done by drip so that the drug can be terminated in time when discomfort occurs.