The combination of furosemide and other diuretic drugs, such as spironolactone, hydrochlorothiazide, tolvaptan, etc., can also be combined with albumin for application, which can achieve certain diuretic effect, but the combination and dose should be chosen according to the specific situation of the patient to avoid damage to the body. Furosemide mainly inhibits the reabsorption of sodium and chloride in the thick segment of the ascending branch of the medullary collaterals of the renal tubules to achieve the diuretic effect. The renal tubules also include the distal tubules, the collecting duct and the distal end of the collecting duct, so the diuretic effect of furosemide alone is not very good. You can consider the combination of diuretic drugs, such as the combination of spironolactone, which can help to avoid hypokalemia, because furosemide is a strong diuretic, which can easily cause hypokalemia, while spironolactone is a potassium preserving diuretic, and the combination of the two drugs can prevent hypokalemia, or the combination of hydrochlorothiazide, which can both can excrete sodium ions as well as potassium ions, or combined with tolvaptan, which helps to enhance the drainage diuretic effect. In addition, albumin can be given intravenously while applying furosemide, which helps to enhance the diuretic effect of furosemide, because albumin can increase the transport of furosemide and enhance the diuretic effect, so the combined use of albumin is also a method of treatment for intractable edema in clinical practice. While applying furosemide, we should pay attention to monitor electrolytes and combine potassium supplementation drugs, such as potassium magnesium mentholate injection, potassium chloride extended-release tablets and potassium citrate granules, to prevent electrolyte disorders, especially hypokalemia, hyponatremia and hypochlorhydria, to avoid affecting health.