A positive Hepatitis B 2.5 item 5, i.e., a positive core antibody (HbcAb) is generally indicative of a previous infection or an asymptomatic HBsAg carrier. Hepatitis B core antibody (HbcAb) is a marker of previous infection, suggesting either a previous infection with the hepatitis B virus, which has cleared but has not produced protective antibodies, or an asymptomatic HBsAg carrier. Hepatitis B core antibody is an early marker of hepatitis B virus infection, usually appearing 3 to 5 weeks after the appearance of surface antigen, and will be detected in the serum before the appearance of hepatitis B symptoms. Core antibody is not protective and does not affect viral replication. A high titer of core antibody sometimes indicates a presenting infection, which can be further determined by testing for HBV-DNA. It is recommended that patients with hepatitis B should consult a doctor in time and follow the doctor’s instructions for examination and treatment, and should not be negligent so as not to delay the condition!