The chances of being infected without hepatitis B antibodies have not been calculated to a specific value, but the chances of being infected without hepatitis B antibodies are relatively greater than with hepatitis B antibodies. The main ways of transmission of the hepatitis B virus are through mother-to-child, blood, body fluids and sexual transmission. When the patient has hepatitis B antibody, after the virus enters the body, the antibody will combine with the antigen of the virus, so that an immune response occurs, eliminating harmful germs and protecting the health of the body, thus preventing viral infection. When the patient does not have hepatitis B antibody, the protective ability of hepatitis B surface antibody is relatively weak, and at this time, if the patient is exposed to hepatitis B through the above channels, the hepatitis B virus may enter the patient’s body quickly. Since there is no antibody that can’t have an immune reaction with the viral antigen, the virus will start to grow and replicate rapidly, and then the patient will be infected. To summarize, when there is no hepatitis B antibody, the chance of infection is relatively high. It is recommended that patients receive hepatitis B vaccination in time and pay attention to the protection in their life to avoid infecting the virus and affecting their life.