Pancreatic cancer is a malignant tumor that occurs in the pancreas, accounting for about 1%-2% of all malignant tumors in the body, with a rising trend in recent years. The head of the pancreas is the most common site of tumor growth, about 60% or more, followed by the tail of the body of the pancreas, and the whole pancreas is the least, accounting for only about 5%. It is more common in males than females, and the high incidence age is 40-65 years old. The disease is the most malignant and the number of deaths ranks fourth in malignant tumors. Because of its insidious clinical manifestations and rapid onset, early diagnosis is very difficult and most of them are already in advanced stages once diagnosed. Typical symptoms of pancreatic cancer include weight loss, loss of appetite, and pain in the abdomen, which can radiate to the back. More than 90% of patients with untreated pancreatic cancer die within one year after diagnosis. At present, the cause of pancreatic cancer is not very clear, mostly related to carcinogenic substances in the environment and chronic diseases such as chronic pancreatitis, chronic cholecystitis, gallbladder stones and diabetes. In addition, the incidence of pancreatic cancer is higher in obese people with long-term high-fat and high-animal protein diet, long-term smoking, and people who are addicted to alcohol and depressed. According to studies, the risk of the disease is three to six times higher in people with the highest smoking indicators than in non-smokers. It is known that obesity was once Pavarotti’s biggest problem, and once he even collapsed on stage and injured his knee due to the overload of his huge body. In addition, he is also known for his eating. That Hong Kong star, like him, is also obese, eats a lot and has suffered from liver and gall bladder disease, which are important reasons for these obese stars to develop pancreatic cancer. The pancreas is located deep in the abdominal cavity and the early symptoms of pancreatic cancer are not so obvious. The main symptoms are discomfort or pain in the upper abdomen, and 60% of patients have these symptoms at the beginning, such as repeated discomfort, pain, fullness, soreness, loss of appetite, nausea, vomiting, diarrhea or constipation, etc., which are sometimes mild and sometimes heavy, and usually more obvious at night, so it is easy to be mistaken for stomach disease and neglected. Some experts consider poor appetite, nausea and vomiting, change in stool habit and weight loss as the four early symptoms of pancreatic tail cancer. In addition, jaundice is the most important clinical manifestation. It is mainly manifested as yellowing of skin and sclera. It is mostly a late manifestation; however, 14% of patients have the first symptom. In the past, painless jaundice was thought to be the typical manifestation of pancreatic head cancer, but in fact, it is not, and most patients are accompanied by abdominal pain of different degrees. Because it is not easy to detect early, only 10%-25% of patients clinically diagnosed with pancreatic cancer can be treated surgically, and the cure rate is very low, so early diagnosis is crucial. what are the manifestations of early pancreatic cancer that should be noted in adults over 40 years old?1. if there is any upper abdominal pain; 2. unexplained anorexia and back pain; 3. unexplained wasting; 4. unexplained obstructive jaundice; 5. Recurrent pancreatitis; 6. Melancholic psychosis without obvious cause; 7. Unexplained thrombophlebitis of the lower extremities; 8. Diabetes mellitus that cannot be explained by other causes. In addition to pancreatic cancer and pancreatic cystic adenocarcinoma, pancreatic tumors also include insulinoma, gastrinoma, islet cell VIP tumor, growth inhibitor tumor, glucagonoma, non-functional islet cell tumor, familial multiple endocrine adenoma and other neuroendocrine tumors with complex and diverse clinical manifestations and a high degree of malignancy. Patients with hypoglycemia or watery diarrhea, intractable peptic ulcer or diabetes mellitus, gallstone disease, diarrhea, steatorrhea or hypokalemia, low or no gastric acid, skin flushing, and watery diarrhea should be alerted to the possibility of endocrine tumors. Endoscopic ultrasound technology (EUS) has been widely used in clinical practice since the 1980s, providing a valuable new method for the diagnosis and differential diagnosis of pancreatic tumors. eus shows a high rate of pancreatic tumors, especially small pancreatic cancer, which is more clearly shown. In addition, intra-ductal ultrasound (IDUS) can show the main pancreatic duct and pancreatic parenchyma, and its sensitivity and specificity are higher than EUS and CT. for pancreatic tumors, only early diagnosis and early treatment can have better results.