Gynecological inflammatory diseases account for the first cause of female infertility. Trichomonas and the large number of leukocytes in various inflammatory vaginal secretions may engulf sperm causing infertility. Bacteria-bearing purulent fluid secreted by cervicitis has a spermicidal effect or the purulent fluid is viscous and unfavorable for sperm to pass through, which may cause infertility. The inflammatory exudate of endometritis has a spermicidal effect; in tuberculous endometritis, the endometrium is destroyed and replaced by tuberculous granulation tissue, which later causes glass-like degeneration or uterine cavity adhesion, so sperm and fertilized eggs cannot pass through or cannot be laid. 1. Gynecological endocrine abnormalities Endocrine abnormalities are the second factor causing infertility, mainly ovulation disorders. It mostly occurs in polycystic ovary syndrome, hyperprolactinemia, normal or low gonadotropic amenorrhea, hypergonadotropic amenorrhea, etc.; followed by luteal insufficiency and changes in the endometrium without adequate secretion period, which affects fertilized egg implantation. 2, endometriosis Among the organic causes of infertility, in addition to inflammation (including tuberculosis), endometriosis takes second place, and endometriosis accounts for 30% to 40% of women with infertility of unknown origin. 3. Abnormal genital development Hymenal atresia, congenital absence of vagina, uterus or ovaries are rare and absolutely infertile. Chromosomal abnormalities, such as karyotype 45, XO. i.e. Turner syndrome, ovarian insufficiency, and anovulation cause infertility. 4. Genital tumors Cervical fibroids block the cervical opening and prevent sperm from moving up. Myoma between the uterine wall deforms the uterine cavity. If the fibroids are located in the two corners of the uterus, they block the entrance of the fallopian tubes and prevent the fertilization of the egg; submucosal fibroids make the endometrium thin, or complicate infection and ulceration, which affect the fertilization of the egg. Bilateral ovarian tumors, or destruction of the solid ovarian cortex, or prolongation and compression of the fallopian tubes due to attachment to the tumor, resulting in the absence of eggs or the inability of eggs to enter the fallopian tubes and infertility. 5. Trauma If the endometrial layer is damaged by heavy scraping, it may lead to adhesions in the uterine cavity, causing obstacles to the passage of sperm and the fertilization of eggs. After the basal layer is damaged, the functional layer cannot grow again, the endometrial cycle changes disappear, and amenorrhea persists. 6. Abnormal uterine position Posterior tilt and retroflexion of the uterus and extreme anterior flexion may cause infertility, and uterine prolapse may cause infertility due to infection, sexual intercourse obstruction or semen drainage.