Many patients’ families worry about the side effects of antipsychotic drugs because patients may experience dull expressions, slow reactions, straightened eyes, slow movements, inflexible limbs, and salivation after taking the drugs. Can taking antipsychotic drugs affect the brain’s intelligence? These symptoms are mostly the adverse effects of antipsychotic drugs, which are inevitable in treatment. While medication is effective, there are inevitably adverse reactions that can give people a feeling of “stupidity”, which are mostly seen with first-generation antipsychotics (such as chlorpromazine). As mentioned earlier, adverse drug reactions such as excessive sedation, extrapyramidal reactions, salivation, and anticholinergic effects can make patients show slow reactions, slow movements, straight eyes, inflexible activities, and sometimes even some consciousness problems, which make patients look “stupid” to the general public. The problem is not entirely intellectual. Currently, the first-line treatment is second-generation antipsychotics, and these reactions are rare and mild.